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Important Information!
***Many different drugs and drug classes have been reported
to cause problems in Collies and other herding breed dogs that carry the MDR1 mutation.
Aussies and other herding types
(Collies, Border Collies, ACD's and Shelties) can have certain drug sensitivities. Aussies should never be given any of
the drugs listed below. Please note Heartgaurd is on the list and can cause seizures in sensitive aussies. Never give Heartguard
to an Aussie, choose Interceptor instead. Also note not all vets are familiar with this list or the MDR1 mutation.
Drugs that
have been documented, or are strongly suspected to cause problems in dogs with the MDR1 mutation:
* Ivermectin (antiparasitic agent) "Heartgaurd"
*
Loperamide (Imodium®; over-the-counter antidiarrheal agent)
* Doxorubicin (anticancer agent)
* Vincristine (anticancer
agent)
* Vinblastine (anticancer agent)
* Cyclosporin (immunosuppressive agent)
* Digoxin (heart drug)
*
Acepromazine (tranquilizer)
*Butorphanol (pain control)
